In Vitro Fertilization (IVF)
In Vitro Fertilization (IVF)
IVF General Information
In 1978, Louise Brown made headlines as the world’s first test-tube baby. This event marked the beginning of the modern age of reproductive medicine. There has been an estimated one million children born through artificial reproductive technologies. In 2004, an expected 200,000 children will be born from In Vitro Fertilization.
IVF is probably the most well known of the “Assisted Reproductive Technologies,” and has helped infertile couples conceive and bear children for over two decades. It was originally developed to help couples overcome tubal factor infertility, but has become useful in treating other factors, such as immunological problems, unexplained infertility and male factor infertility.
There are now treatments for virtually any reproductive problem from the most severe sperm problems to the use of donor oocytes to combat the effects of maternal aging.
The Odds of Success
Women under age 35 without a male infertility factor involved have an average 40-50 % (percent) chance of conceiving and giving birth to a baby using IVF in our clinic over the past ten years. Success typically increases with the number of cycles attempted. You can access the success rates of fertility clinics in the United States through CDC website (see our success page for more information).
New Delopments in IVF
In a study of our pregnancy rates over the past two years, we have found that the use of segmented IVF cycles have produced a 5-8% increase in pregnancy rates over the conventional IVF rates. Segmented IVF cycles are ones where the embryo transfer is not done in the fresh stimulated IVF cycle. All of the embryos are frozen and therefore no fresh embryo transfer is performed. Cryopreserved embryos are subsequently used in a programmed frozen embryo transfer cycle.The increased pregnancy rates in these cycles are due to several factors. First, in stimulated IVF cycles, the endometrial lining is slightly out of phase with the embryo development. Secondly, the endometrial development can be over stimulated (thicker) or under developed when compared to normal physiologic cycles. Thirdly, the ovaries in these cycles are hyperstimulated and are at an increased risk for ovarian hyperstimulation syndrome (OHSS) should a pregnancy result from the fresh transfer.Segmented IVF is able to eliminate all of these shortcomings. Our embryo survival rate from the freeze/thaw process was over 95% in the past two years so virtually none of the embryos are lost secondary to freezing them.
This allows us to use a programmed hormone replacement cycle to create an ideal physiologic endometrial lining and precise timing for the embryo transfer. Since the ovaries are not stimulated it eliminates ovarian hyperstimulation syndrome.
The combination of these factors has resulted in a 5-8% increase in pregnancy rates over our already high IVF pregnancy rates.